Author

A. J. Ryan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Y. Jiang· 2 shared A. G. Grieve· 1 shared A. Nandakumar· 1 shared B. Sieber· 1 shared C. Brown· 1 shared C. J. Benson· 1 shared D. Ebner· 1 shared D. M. Collier· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 7 mutual co-author links

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2 shared papersCancer Biology

Y. Jiang

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Acid enhances salt taste by activating the epithelial sodium channel

D. M. Collier, Z. J. Peterson, A. J. Ryan, N. N. Williford, C. J. Benson, P. M. Snyder

The paper shows acid enhances salt taste by modulating ENaC channel activity, with acidic beverages like Coca-Cola and Pepsi stimulating ENaC current while Diet Coke does not.

bioRxiv · Apr 14, 2023 · PreprintPhysiology

Radiation-induced persistent DNA damage response and late toxicity in cardiac tissue

K. Shigemori, Y. Jiang, J. C. Martin, M. A. Hawkins, A. J. Ryan, E. E. Parkes

This study investigates early and late cardiac toxicity in irradiated A/J mice, identifying persistent DNA damage and macrophage polarization as potential contributors to long-term cardiac complications.

bioRxiv · Feb 27, 2023 · PreprintCancer Biology

iRhom2 regulates ERBB signalling to promote KRAS-driven oncogenesis

B. Sieber, F. Lu, S. M. Stribbling, A. G. Grieve, A. J. Ryan, M. Freeman

This study shows that iRhom2 promotes KRAS-driven oncogenesis by enhancing ADAM17-dependent shedding of ERBB ligands through phosphorylation and 14-3-3 protein recruitment.

bioRxiv · Aug 6, 2021Cancer Biology

IGF targeting perturbs global replication through ribonucleotide reductase dysfunction

G. Rieunier, X. Wu, L. Harris, J. Mills, A. Nandakumar, L. Colling, E. Seraia, S. B. Hatch, D. Ebner, L. Folkes, U. Weyer-czernilofsky, T. Bogenrieder, A. J. Ryan, V. M. Macaulay

This study shows that IGF-1R inhibition causes replication stress by reducing RNR subunit RRM2, leading to DNA damage and synthetic lethality with ATM loss in cancer cells.

bioRxiv · Aug 11, 2020Cancer Biology

Hippo Pathway Deregulation Drives Tissue Stiffness and Cancer Stem-like Cells in Lung Adenocarcinoma

D. Pankova, Y. Jiang, I. Vendrell, J. Buzzelli, A. J. Ryan, C. Brown, E. O'Neill

This study shows that epigenetic silencing of RASSF1A and increased P4HA2 activity drive tissue stiffness and cancer stem-like properties in lung adenocarcinoma, with potential therapeutic implications.

bioRxiv · Aug 13, 2018Cancer Biology