Author

B. Siemons

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:electrophysiology· 1 Assay:organoid / primary culture· 1

Frequent Co-Authors

V. Charwat· 3 shared A. Edwards· 2 shared B. Charrez· 2 shared E. Miller· 2 shared K. Healy· 2 shared N. Huebsch· 2 shared S. C. Boggess· 2 shared A. Laemmle· 1 shared

Activity by Year

2020-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersBioengineering

V. Charwat

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

In Vitro Safety "Clinical Trial" of the Cardiac Liability of Hydroxychloroquine and Azithromycin as COVID19 Polytherapy

B. Charrez, V. Charwat, B. Siemons, H. Finsberg, A. Edwards, E. Miller, K. Healy

This paper uses a cardiac microphysiological system to assess the cardiotoxicity of hydroxychloroquine and azithromycin polytherapy, finding increased QT interval and reduced arrhythmias compared to monotherapy.

bioRxiv · Dec 21, 2020 · PreprintBioengineering

Metabolically-Driven Maturation of hiPSC-Cell Derived Heart-on-a-Chip

N. Huebsch, B. Charrez, B. Siemons, S. C. Boggess, S. Wall, G. Neiman, V. Charwat, K. Jaeger, F. L. T. Montiel, N. C. Jeffreys, N. Deveshwar, A. Edwards, J. Serrano, M. Snuderl, A. Stahl, , K. E. Healy

This study improves electrophysiological maturation of hiPSC-derived cardiomyocytes by combining metabolic cues and biophysical stimuli, revealing genotype-dependent responses to maturation media.

bioRxiv · Nov 14, 2020Bioengineering

Integrated hiPSC-based liver and heart microphysiological systems predict unsafe drug-drug interaction

F. T. Lee-Montiel, A. Laemmle, L. Dumont, C. S. Lee, N. Huebsch, V. Charwat, H. Okochi, M. J. Hancock, B. Siemons, S. C. Boggess, I. Goswami, E. Miller, H. Willenbring, K. Healy

The paper integrates hiPSC-based liver and heart microphysiological systems to predict drug-drug interactions, showing ketoconazole inhibits cisapride metabolism, causing arrhythmia in cardiac MPSs.

bioRxiv · May 24, 2020 · PreprintBioengineering