S. Wall

Do calcium channel blockers applied to cardiomyocytes cause increased channel expression resulting in reduced efficacy?

The paper investigates whether calcium channel blockers like nifedipine reduce efficacy in cardiomyocytes by inducing increased calcium channel expression due to intracellular calcium level changes.

Computational prediction of drug response in short QT syndrome type 1 based on measurements of compound effect in stem cell-derived cardiomyocytes

The paper develops a computational method to predict adult drug responses from in vitro measurements of patient-derived stem cell cardiomyocytes in short QT syndrome.

Cross-reactive coronavirus antibodies with diverse epitope specificities and extra-neutralization functions

The paper identifies cross-reactive antibodies against multiple coronaviruses, showing they target diverse epitopes and mediate effector functions.

Metabolically-Driven Maturation of hiPSC-Cell Derived Heart-on-a-Chip

This study improves electrophysiological maturation of hiPSC-derived cardiomyocytes by combining metabolic cues and biophysical stimuli, revealing genotype-dependent responses to maturation media.

Identifying drug response by combining measurements of the membrane potential, the cytosolic calcium concentration, and the extracellular potential in microphysiological systems

The paper combines membrane potential, cytosolic calcium, and extracellular potential measurements to accurately estimate sodium channel current density and drug effects in hiPSC-CMs.

Improved computational identification of drug response using optical measurements of human stem cell derived cardiomyocytes in microphysiological systems

The paper improves computational methods to identify drug responses in mature human stem cell-derived cardiomyocytes using optical measurements and mathematical modeling.

Inversion and computational maturation of drug response using human stem cell derived cardiomyocytes in microphysiological systems

This paper develops a computational framework to predict drug effects in mature cardiomyocytes using data from immature human stem cell-derived cardiomyocytes in microphysiological systems.

Transcriptomes of major renal collecting-duct cell types in mouse identified by single-cell RNA-Seq

The paper identifies transcriptomes of major renal collecting-duct cell types in mice using single-cell RNA-Seq and creates an online gene-expression database.