E. Miller

Leveraging Crosslinker Diffusion to Template Stiffness Gradients in Alginate Hydrogels

This paper develops a method to create stiffness gradients in alginate hydrogels using stencils, enabling the study of mechanosensitive cell behaviors like cancer cell invasion.

Towards optical measurements of membrane potential values in Bacillus subtilis using fluorescence lifetime

This paper introduces a fluorescence lifetime-based method to measure membrane potential in Bacillus subtilis, achieving single-cell resolution and quantification of MP changes under chemical perturbations.

Restoration of metabolic functional metrics from label-free, two-photon cervical tissue images using multiscale deep-learning-based denoising algorithms

The paper develops a multiscale deep-learning denoising algorithm to restore metabolic function metrics from low-SNR two-photon images of human cervical tissue.

Multi-frame biomechanical and relaxometry analysis during in vivo loading of the human knee by spiral dualMRI and compressed sensing

This study uses spiral DENSE MRI and compressed sensing to analyze knee cartilage biomechanics during in vivo loading, showing strain patterns and reduced scan times.

KATP Channel Prodrugs Reduce Inflammatory and Neuropathic Hypersensitivity, Morphine Induced Hypersensitivity, and Precipitated Withdrawal in Mice

This study evaluates KATP channel prodrugs in pain models, showing reduced hypersensitivity and opioid tolerance in mice.

Long-term, super-resolution HIDE imaging of the inner mitochondrial membrane in live cells with a cell-permeant lipid probe

High-frame-rate analysis of knee cartilage deformation by spiral dualMRI and relaxation mapping

This study uses high-frame-rate MRI and relaxometry to analyze knee cartilage deformation during walking, identifying strain patterns and viscoelastic responses that differentiate healthy from damaged joints.

11β-HSD1 inhibition does not affect murine tumour angiogenesis but may exert a selective effect on tumour growth by modulating inflammation and fibrosis

This study investigates the effect of 11β-HSD1 inhibition on tumour growth and angiogenesis in murine models, finding increased SCC tumour growth but no effect on angiogenesis.

Mutation rate dynamics reflect ecological change in an emerging zoonotic pathogen

The paper investigates how mutation rates in Streptococcus suis change with ecology and genome size, finding higher mutation rates in invasive disease isolates and a bias towards G/C to A/T mutations in more pathogenic strains.

Optical Estimation of Absolute Membrane Potential Using One- and Two-Photon Fluorescence Lifetime Imaging Microscopy

This paper demonstrates the use of fluorescence lifetime imaging microscopy (FLIM) with a voltage-sensitive dye to estimate absolute membrane potential values with high accuracy across different imaging platforms.

In Vitro Safety "Clinical Trial" of the Cardiac Liability of Hydroxychloroquine and Azithromycin as COVID19 Polytherapy

This paper uses a cardiac microphysiological system to assess the cardiotoxicity of hydroxychloroquine and azithromycin polytherapy, finding increased QT interval and reduced arrhythmias compared to monotherapy.

The Wood Image Analysis and Dataset (WIAD): open-access visual analysis tools to advance the ecological data revolution

The paper introduces WIAD, an open-source tool for visual analysis of wood images to improve transparency and reproducibility in ecological studies.

Integrated hiPSC-based liver and heart microphysiological systems predict unsafe drug-drug interaction

The paper integrates hiPSC-based liver and heart microphysiological systems to predict drug-drug interactions, showing ketoconazole inhibits cisapride metabolism, causing arrhythmia in cardiac MPSs.

Feasibility analysis of semiconductor voltage nanosensors for neuronal membrane potential sensing

This study develops semiconductor voltage-sensitive nanorods for neuronal membrane potential sensing and demonstrates their feasibility for single-particle detection.

Inosine is an alternative carbon supply that supports effector T cell proliferation and anti-tumor function under glucose restriction

This study shows that effector T cells use inosine as an alternative carbon source under glucose restriction, enhancing anti-tumor function and bypassing tumor-imposed metabolic limitations.

Optical determination of absolute membrane potential

The paper develops a fluorescence lifetime-based method to optically measure absolute membrane potential in cells and demonstrates its application in human carcinoma cells.

Microbial associations and spatial proximity predict North American moose (Alces alces) gastrointestinal community composition

The paper investigates how microbial associations and spatial proximity influence gut microbial community composition in North American moose.

Eavesdropping and crosstalk between quorum sensing peptide signals that regulate bacteriocin production in Streptococcus pneumoniae

The paper investigates social interactions in Streptococcus pneumoniae by analyzing QS signals and receptors, revealing eavesdropping and crosstalk that influence bacteriocin production.