Metabolically-Driven Maturation of hiPSC-Cell Derived Heart-on-a-Chip
N. Huebsch, B. Charrez, B. Siemons, S. C. Boggess, S. Wall, G. Neiman, V. Charwat, K. Jaeger, F. L. T. Montiel, N. C. Jeffreys, N. Deveshwar, A. Edwards, J. Serrano, M. Snuderl, A. Stahl, , K. E. Healy
This study improves electrophysiological maturation of hiPSC-derived cardiomyocytes by combining metabolic cues and biophysical stimuli, revealing genotype-dependent responses to maturation media.
bioRxiv · Nov 14, 2020Bioengineering