MAP4K3 inhibits Sirtuin-1 to repress LKB1-AMPK to promote amino acid dependent activation of mTORC1
A. La Spada, M. R. Branch, C. Hsu, K. Ohnishi, E. Lee, J. Meisenhelder, B. J. Winborn, B. Sopher, J. P. Taylor, T. Hunter
This study identifies a novel pathway where MAP4K3 inhibits Sirtuin-1 to suppress LKB1-AMPK, thereby activating mTORC1 in response to amino acids.
bioRxiv · Nov 8, 2021Cell Biology