C. Hsu

Development of highly multiplex targeted proteomics assays in biofluids using the Stellar mass spectrometer

The paper develops scalable targeted proteomics assays using the Stellar mass spectrometer for analyzing biofluids, demonstrating high sensitivity and multiplexing capabilities.

Proteomic Analysis Reveals a PLK1-Dependent G2/M Degradation Program and Links PKA-AKAP2 to Cell Cycle Control

The paper uses proteomics and PLK1 inhibition to identify proteins degraded at G2/M, showing PLK1's role in coordinating proteolysis via SCF ligases and linking AKAP2 to cell cycle control.

Evaluating the performance of the Astral mass analyzer for quantitative proteomics using data independent acquisition

The paper evaluates the Astral mass analyzer's performance in quantitative proteomics, showing it quantifies 5 times more peptides per unit time than existing Orbitrap mass spectrometers and detects over 5,000 plasma proteins.

Chromatin Remodeling in Patient-Derived Colorectal Cancer Models

This study compares chromatin remodeling in colorectal cancer patient-derived models and identifies transcription factors driving differences in growth and drug response.

MAP4K3 inhibits Sirtuin-1 to repress LKB1-AMPK to promote amino acid dependent activation of mTORC1

This study identifies a novel pathway where MAP4K3 inhibits Sirtuin-1 to suppress LKB1-AMPK, thereby activating mTORC1 in response to amino acids.

A novel exosome biogenesis mechanism: multivesicular structures budding and rupturing at the plasma membrane

The paper identifies a novel exosome release mechanism where multivesicular structures protrude from the plasma membrane and rupture to release exosomes, distinct from the conventional multivesicular endosome fusion process.