Cell BiologybioRxiv
MAP4K3 inhibits Sirtuin-1 to repress LKB1-AMPK to promote amino acid dependent activation of mTORC1
A. La Spada, M. R. Branch, C. Hsu…·T. Hunter
This study identifies a novel pathway where MAP4K3 inhibits Sirtuin-1 to suppress LKB1-AMPK, thereby activating mTORC1 in response to amino acids.
DOI 10.26508/lsa.202201525