Lymphatic Dysfunction Models an Autoimmune Emphysema Phenotype of Chronic Obstructive Pulmonary Disease
B. Summers, K. Kim, T. M. Lu, S. Houghton, J. R. Quintero, J. Cala-Garcia, T. Pannellini, F. Polverino, R. Lis, A. Trivedi, H. O. Reed
This study shows that lymphatic dysfunction drives lung injury and autoimmune emphysema in COPD by promoting TLO formation and autoantibody production in mice, with similar patterns observed in human COPD patients.
bioRxiv · Oct 31, 2023 · PreprintPathology