K. Kim

Effects of clinically relevant radionuclides on the activation of a type I interferon response by radiopharmaceuticals in syngeneic murine tumor models

This study examines how different radionuclides affect the type I interferon response in tumor models and shows that 225Ac enhances immunotherapy response via STING-dependent mechanisms.

FLASH proton reirradiation, with or without hypofractionation, mitigates chronic toxicity in the normal murine intestine, skin, and bone.

Cyclophilin A Facilitates HIV-1 DNA Integration

This study shows that Cyclophilin A promotes HIV-1 integration by enhancing preintegration complex activity, revealing a new role for CypA in the viral life cycle.

Triptolide sensitizes cancer cells to nucleoside DNA methyltransferase inhibitors through inhibition of DCTPP1-mediated cell-intrinsic resistance

This paper identifies triptolide as a compound that enhances the effectiveness of DNMTi by inhibiting DCTPP1, overcoming resistance in cancer cells.

Collagen fibril formation at the plasma membrane occurs independently from collagen secretion

The paper investigates collagen fibril formation in fibroblasts, showing it occurs at the plasma membrane independently of secretion and involves endocytosis.

3D bioprinting of Liver Microenvironment Model Using Photocrosslinkable Decellularized Extracellular Matrix based Hydrogel

This paper develops a photocrosslinkable liver decellularized extracellular matrix hydrogel for 3D bioprinting, showing enhanced liver cell proliferation and function.

Enhanced extracellular matrix remodeling due to embedded spheroid fluidization

This study uses a computational model to show that fluid-like tumor spheroids cause more ECM remodeling than solid-like spheroids due to shape fluctuations and cellular motility.

Optical characterization of molecular interaction strength in protein condensates

The paper introduces optical techniques to measure molecular interaction strength and physical properties of protein condensates, showing how sequence variations and environmental factors affect these properties.

Direct Ink Writing of Graphene Oxide Reinforced 13-93B1 Bioactive Glass Scaffolds for Bone Tissue Engineering Applications

This paper fabricates graphene oxide-reinforced 13-93B1 bioactive glass scaffolds using direct ink writing and evaluates their mechanical, structural, and biological properties for bone tissue engineering.

Assessing Long-Term Stored Tissues for Multi-Omics Data Quality and Proteogenomics Suitability

This study evaluates the quality and suitability of long-term stored tissues for multi-omics analyses, showing that while transcriptomic data show some changes, core gene expression and proteomic measurements remain reliable.

Molecular mechanism for regulating APOBEC3G DNA editing function by the non-catalytic domain

This study identifies how AA/GA dinucleotides downstream of target-C sites enhance APOBEC3G DNA editing through structural and biochemical analysis of rhesus macaque A3G.

Environmental and Historical Determinants of African Horse Sickness: Insights from Predictive Modeling

This study uses predictive modeling to analyze global patterns of African Horse Sickness, identifying high-risk areas and highlighting the impact of climate on disease transmission.

Binding Position Dependent Modulation of Smoothened Activity by Cyclopamine

This study uses simulations to show cyclopamine acts as an agonist when bound to the CRD of Smoothened and as an antagonist when bound to the TMD, with mixed effects when bound to both sites.

Stratification of viral shedding patterns in saliva of COVID-19 patients

This study stratifies SARS-CoV-2 viral shedding patterns in saliva into three groups with distinct durations using a mathematical model and clustering, but finds no clear clinical or miRNA biomarkers explaining the differences.

The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravir

This paper identifies the mechanism of resistance to the HIV-1 integrase inhibitor pirmitegravir and develops a more potent analog to overcome this resistance.

Beyond comparison: Brillouin microscopy and AFM-based indentation reveal divergent insights into the mechanical profile of the murine retina

This study compares Brillouin microscopy and AFM-based indentation to assess mechanical properties of murine retinal tissues, finding divergent results and highlighting their complementary nature.

Molecular mechanism of β-arrestin-2 interaction with phosphatidylinositol 4,5-bisphosphate

This study investigates how PIP2 binding to the C-domain of β-arrestin-2 induces conformational changes leading to its activation.

AlphaFold2 structures template ligand discovery

This study evaluates AlphaFold2 models for ligand discovery, finding they perform similarly to experimental structures despite conformational differences, and identify potent agonists for the 5-HT2A receptor.

Genomic hypomethylation in cell-free DNA predicts responses to checkpoint blockade in lung and breast cancer

This study develops iMethyl, a method to estimate genomic hypomethylation from cell-free DNA to predict responses to immune checkpoint blockade in cancer patients.

Global organelle profiling reveals subcellular localization and remodeling at proteome scale

The paper maps subcellular localization of human proteins and shows proteome remodeling during viral infection by combining organelle immuno-capture with mass spectrometry.

RNA-guided RNA silencing by an Asgard archaeal Argonaute

The paper identifies an Asgard archaeal Argonaute, HrAgo1, that performs RNA-guided RNA silencing, bridging the gap between prokaryotic and eukaryotic Argonaute mechanisms.

Estimation of the mass density of biological matter from refractive index measurements

This paper estimates mass density from refractive index measurements using a method that incorporates biochemical composition assumptions and uncertainty analysis, validated on biological samples.

Paleolithic Gene Duplications Primed Adaptive Evolution of Human Amylase Locus Upon Agriculture

The paper resolves the amylase locus at nucleotide resolution in modern and ancient humans, showing AMY1 copy number variation predated agriculture and was driven by recombination.

TRPS1 maintains luminal progenitors in the mammary gland by repressing SRF/MRTF activity

This study shows TRPS1 maintains luminal progenitors in the mammary gland by repressing SRF/MRTF activity, linking it to mechanotransduction and breast cancer initiation.

Vascularized Liver Tissue Embedded Bioprinting Utilizing GelMA/Nanoclay-based Composite hydrogels

This study develops a GelMA/nanoclay composite hydrogel for vascularized liver tissue bioprinting, optimizing its properties to support cell behavior and perfusion.

Photobody formation spatially segregates two opposing phytochrome B signaling actions to titrate plant environmental responses

The paper shows that phytochrome B forms photobodies to spatially separate and balance opposing effects on PIF5, enabling environmentally sensitive regulation of plant responses.

Lymphatic Dysfunction Models an Autoimmune Emphysema Phenotype of Chronic Obstructive Pulmonary Disease

This study shows that lymphatic dysfunction drives lung injury and autoimmune emphysema in COPD by promoting TLO formation and autoantibody production in mice, with similar patterns observed in human COPD patients.

Global control of cellular physiology by biomolecular condensates through modulation of electrochemical equilibria

This study shows that biomolecular condensates modulate electrochemical gradients in cells, affecting gene expression, membrane potential, and bacterial survival under antibiotic stress.

A compact, ultrahigh-density headstage with high-fidelity hybrid integration for large-scale deep-brain opto-electrophysiology

This paper introduces a high-channel-count optogenetic system for deep-brain studies, achieving high spatial resolution in recording and stimulation with unprecedented channel density.

Stereotypic persistent B cell receptor clonotypes in Alzheimer's Disease

The paper identifies stereotypic BCR clonotypes in Alzheimer's Disease patients that persist over time and are not found in healthy controls, suggesting potential diagnostic signatures.