Bakthisaran Raman

The paper investigates how lipid-protein interactions constrain sequence evolution in membrane subunits of eukaryotic respiratory complexes, finding that lipid-exposed surfaces show non-PPI disease mutations and kingdom-specific lipid unsaturation affects stability.

This study investigates how the R54C mutation in αA-crystallin causes cataract by altering its interactome and increasing nucleosomal association, rather than reducing chaperone activity.