The K18-hACE2 mouse model of SARS-CoV-2 infection to illustrate the role and response of the vasculature in neurotropic viral infection
Simon De Neck, Rebekah Penrice-Randal, Leandro Xavier Neves, Frauke Seehusen, Parul Sharma, Barbara Helminger, Adam Kirby, Daniele Mega, Maximilian Erdmann, Martina Zanella, Michelle E. Reid, Edward Emmott, Giuseppe Balistreri, Alaa Othman, Udo Hetzel, , Anja Kipar
This study uses a K18-hACE2 mouse model to show SARS-CoV-2 infects neurons in the brain without damaging blood vessels, leading to limited neuroinflammation.
bioRxiv · Feb 7, 2025 · PreprintPathology