Anja Kipar

This study examines histopathological and viral protein expression features of Boid Inclusion Body Disease in boa constrictors, finding higher IB and NP scores in recent cases and no significant link between NP scores and inflammation.

This study evaluates the pharmacokinetics, biodistribution, and therapeutic efficacy of a trimeric nanobody against SARS-CoV-2 in golden Syrian hamsters, showing that intranasal administration provides effective respiratory exposure and therapeutic benefit.

This study identifies Tmem117 as an oligodendrocyte-enriched regulator of NCX activity, linking myelin homeostasis to counterregulatory response and metabolic health.

This study shows that targeting the CCR2 inflammatory pathway reduces severe disease and pulmonary inflammation in a mouse model of SARS-CoV2 infection.

This study investigates the biodistribution and effects of Ronapreve in a mouse model of SARS-CoV-2 infection, showing it does not reach the brain but reduces viral loads in the lung and brain.

This study investigates the protein expression of Swiss snake colony virus 1 (SwSCV-1) and finds it encodes only a single form of the delta antigen, unlike hepatitis D virus (HDV), and the additional ORF2 does not produce a functional protein.

This study shows that HIF activation limits pneumovirus replication by enhancing innate immune sensing and reducing viral RNA methylation.

This paper introduces a rapid rPMMA workflow for molecular histopathology of calcified temporal bones, reducing processing time and costs by 90% while enabling advanced molecular assays.

This study identifies two potent nanobodies targeting the conserved S2 region of SARS-CoV-2 spike protein that resist viral escape and reduce viral load in a hamster model.

The paper identifies a novel macrophage-like population in exocrine glands sustained by ILC2-derived GM-CSF, showing conservation across species.

This study identifies immune repertoire changes and viral evolution in feline coronavirus infection, linking them to FIP severity and outcomes.

This study shows SARS-CoV-2 infects hiPSC-derived neurons via endosomal-lysosomal pathway dependent on cathepsins, leading to HIF1alpha accumulation and phosphorylated tau, suggesting neurodegenerative effects.

This study identifies GM-CSF-producing helper T cells as drivers of immunopathology, showing Treg cells restrain them to prevent tissue damage in mice.

This paper develops a modular adapter system to target dendritic cells with adenoviral vectors, enhancing tumor vaccination by improving DC transduction and co-delivering cytokines.

This study examines how molnupiravir and nirmatrelvir affect SARS-CoV-2 genome diversity in immunocompromised mice, finding reduced viral load and specific mutations but no major consensus sequence changes.

This study re-establishes the golden Syrian hamster as an MCF model and identifies T cells and macrophages as key infected cells, with broader viral tropism including endothelial cells and epithelia.

This study uses a K18-hACE2 mouse model to show SARS-CoV-2 infects neurons in the brain without damaging blood vessels, leading to limited neuroinflammation.

This study identifies two bovine-derived monoclonal antibodies with ultra-long CDRH3 domains that broadly neutralize SARS-CoV-2 and sarbecoviruses.

The paper examines the morphology of haemolymphatic tissues in healthy and Boid Inclusion Body Disease (BIBD)-affected boa constrictors, identifying structural features and disease-related changes.

This study shows that an Ascophyllum nodosum extract inhibits influenza virus infection by targeting virions and neuraminidase activity, reducing viral load in mice.

The paper reports on neoplastic vascular proliferations in rainbow boas with boid inclusion body disease, linking reptarenavirus infection to potential neoplastic processes.

This study shows that hypoxia inducible factors (HIFs) suppress RSV infection by reducing nucleolin expression and inhibiting viral replication and inflammation.

This study shows that a recombinant SARS-CoV-2 virus lacking ORF10 start and internal methionine codons is attenuated in hamsters, with reduced lower respiratory tract viral titre and increased reversion to wild-type.

This study shows that combining PIKfyve and TMPRSS2 inhibitors intranasally protects mice from SARS-CoV-2 lung infection and reduces cell death.

The paper introduces a 1.2x genome infectious clone strategy for deltaviruses, demonstrating its ability to initiate replication in snake cells without helper viruses.