Rebekah Penrice-Randal

This study identifies the ERAD and proteasome pathways as regulators of HEV pORF1 proteostasis and genome replication.

This study investigates the biodistribution and effects of Ronapreve in a mouse model of SARS-CoV-2 infection, showing it does not reach the brain but reduces viral loads in the lung and brain.

This paper introduces a plasmid-based system using vaccinia virus capping enzymes to enhance calicivirus reverse genetics in mammalian cells, significantly increasing viral titres and polyprotein abundance.

This study shows that HIF activation limits pneumovirus replication by enhancing innate immune sensing and reducing viral RNA methylation.

This study examines how molnupiravir and nirmatrelvir affect SARS-CoV-2 genome diversity in immunocompromised mice, finding reduced viral load and specific mutations but no major consensus sequence changes.

This study uses a K18-hACE2 mouse model to show SARS-CoV-2 infects neurons in the brain without damaging blood vessels, leading to limited neuroinflammation.

The paper identifies a new CECoV variant associated with seasonal outbreaks of severe canine gastroenteritis and shows its genetic relationship to a 2020 variant, but not to human respiratory-related CECoV-like viruses.

The paper develops an amplicon-based sequencing method for rapid MERS-CoV genotyping and evaluates it alongside metagenomic analysis to study the microbiome in MERS patients.

The paper compares immune responses in influenza and SARS-CoV-2 infected patients and COVID-19 survivors using transcriptomic data, identifying distinct immune signatures and prognostic indicators.