Cryo-EM confirms a common fibril fold in the heart of four patients with ATTRwt amyloidosis
Binh An Nguyen, Virender Singh, Shumaila Afrin, Preeti Singh, Maja Pekala, Yasmin Ahmed, Rose Pedretti, Jacob Canepa, Andrew Lemoff, Barbara Kluve-Beckerman, Pawel M. Wydorski, Farzeen Chhapra, Lorena Saelices
The paper uses cryo-EM to show that cardiac ATTRwt amyloid fibrils from four patients are structurally identical, supporting their consistent clinical presentation.
bioRxiv · Mar 8, 2024Biophysics