Author

Farzeen Chhapra

The University of Texas Southwestern Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:protein structure prediction· 3 Assay:cryo-EM· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:protein structure· 1

Frequent Co-Authors

Binh An NguyeniD· 3 shared Lorena SaelicesiD· 3 shared Preeti SinghiD· 3 shared Rose PedrettiiD· 3 shared Shumaila AfriniD· 3 shared Virender Pratap SinghiD· 3 shared Yasmin AhmediD· 3 shared Andrew S. LemoffiD· 2 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiophysics

Binh An NguyenORCID

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Author profile →

3 papers

Recent·Most cited

A Shared Amyloid Architecture in Cardiac Fibrils from Three Neuropathy-Associated ATTR Variants

María del Carmen Fernández‐Ramírez, Shumaila Afrin, Binh An Nguyen, Virender Pratap Singh, Maja Pękała, Preeti Singh, Yasmin Ahmed, Rose Pedretti, Andrew S. Lemoff, Barbara Kluve‐Beckerman, Farzeen Chhapra, David S Eisenberg, Lorena Saelices

The paper determines the cryo-EM structures of three neuropathy-associated ATTR variants and reveals a shared amyloid core despite different mutations and clinical phenotypes.

bioRxiv · Aug 5, 2025 · PreprintBiophysics

Cryo-EM confirms a common fibril fold in the heart of four patients with ATTRwt amyloidosis

Binh An Nguyen, Virender Singh, Shumaila Afrin, Preeti Singh, Maja Pekala, Yasmin Ahmed, Rose Pedretti, Jacob Canepa, Andrew Lemoff, Barbara Kluve-Beckerman, Pawel M. Wydorski, Farzeen Chhapra, Lorena Saelices

The paper uses cryo-EM to show that cardiac ATTRwt amyloid fibrils from four patients are structurally identical, supporting their consistent clinical presentation.

bioRxiv · Mar 8, 2024Biophysics

Structural polymorphism of amyloid fibrils in cardiac ATTR amyloidosis revealed by cryo-electron microscopy

Binh An Nguyen, Shumaila Afrin, Virender Pratap Singh, Yasmin Ahmed, Rose Pedretti, María del Carmen Fernández‐Ramírez, Merrill Douglas Benson, Michael R. Sawaya, Preeti Singh, Qin Cao, David R. Boyer, Alexander Pope, Paweł M. Wydorski, Siddharth Kumar, Farzeen Chhapra, , Lorena Saelices

The paper uses cryo-electron microscopy to show that cardiac ATTR amyloid fibrils are structurally polymorphic, independent of genotype and phenotype, challenging the one-fibril-fold-per-disease paradigm.

bioRxiv · Jun 21, 2022 · PreprintMolecular Biology