Paweł M. Wydorski

This study shows DnaJB1 inhibits tau aggregation by binding its N-terminus in vitro and in cellular models, with interactions enhanced by polyanionic factors.

The paper uses cryo-EM to show that cardiac ATTRwt amyloid fibrils from four patients are structurally identical, supporting their consistent clinical presentation.

The paper uses cryo-electron microscopy to show that cardiac ATTR amyloid fibrils are structurally polymorphic, independent of genotype and phenotype, challenging the one-fibril-fold-per-disease paradigm.