Subthreshold perturbation of DNA replication induces a secretory response and a bystander effect in naïve human fibroblasts
Benedetta Perdichizzi, Floriana Cappiello, Flavia Di Feo, Loredana Le Pera, Alfredo Pagliuca, Pasquale Valenzisi, Marco Rosina, Daniela Merlo, Annapaola Franchitto, Pietro Pichierri
The paper shows that low-dose DNA replication perturbation in fibroblasts triggers a secretory response and bystander effect without DNA damage.
bioRxiv · Aug 21, 2026 · PreprintCell Biology