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The paper introduces a biosensor to detect reversed replication forks and four-way junctions in human cells, enabling spatial analysis of DNA structures in situ.

The paper shows that low-dose DNA replication perturbation in fibroblasts triggers a secretory response and bystander effect without DNA damage.

This study identifies a WRNIP1-ATM-FANCJ pathway that resolves G-quadruplexes by stabilizing FANCJ, preventing genome instability.

This paper shows that HPV16 requires SMARCAL1 to recruit to viral and host replication forks, which is essential for its life cycle and prevents DNA damage and genome integration.

This study identifies phosphorylation events on WRN that regulate end-resection and RAD51-mediated repair at replication forks.

This study shows SAMHD1 influences WRN recruitment to DSBs and their cooperative role in DNA repair, with SAMHD1 compensating for WRN deficiency in some contexts.