TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism
Astrid Feiten, Kilian Dahm, Kai Schlepckow, Bettina van Lengerich, Jung H. Suh, Anika Reifschneider, Benedikt Wefers, Laura M. Bartos, Karin Wind-Mark, Lis de Weerd, T Ulas, Elena De Domenico, Pia Grundschöttel, Stefan Paulusch, Benjamin Tast, , Christian Haass
This study investigates how TREM2 expression levels affect microglial function, metabolism, and response to TREM2 agonists in a mouse model of Alzheimer's disease.
Nature Communications · Jan 24, 2026Peer-reviewedNeuroscience