Kai Schlepckow

This study shows TREM2 agonism in clonal hematopoiesis enhances fibrous cap formation via macrophage-derived PDGFB and stromal PDGFR? signaling, increasing specific fibroblast populations and reducing macrophage migration.

This study investigates how TREM2 expression levels affect microglial function, metabolism, and response to TREM2 agonists in a mouse model of Alzheimer's disease.

This study shows that long-term anti-Aβ treatment reduces amyloid plaques and microglial activation but leaves residual plaques with persistent immune activity.

This study identifies iRhom2 as a modifier of ADAM17-mediated TREM2 proteolysis in microglia, linking it to Alzheimer's disease risk.

The paper investigates how structural dynamics of TREM2's transmembrane helix influence its intramembrane cleavage by gamma-secretase, linking flexibility to cleavage site specificity.