Alessio Ricci

This study investigates how TREM2 expression levels affect microglial function, metabolism, and response to TREM2 agonists in a mouse model of Alzheimer's disease.

LipiGo is a DNA-lipid nanoparticle hybrid that enables efficient delivery of functional mRNA to non-hepatic tissues, particularly the spleen, through passive redistribution and active targeting.

This study identifies innate immune memory after brain injury as a driver of chronic cardiac dysfunction, showing that post-stroke epigenetic changes in myeloid cells lead to inflammation and fibrosis in the heart.