Bo Pang

Prevention of Unc13a cryptic splicing is sufficient to preserve memory

This study shows that preventing cryptic splicing of UNC13A and other TDP-43 targets can preserve memory and reduce neuron loss in a TDP-43 knockout mouse model.

Immune cells regulate circulating adipocyte extracellular vesicle levels in response to metabolic shifts

The paper shows immune cells regulate circulating adipocyte extracellular vesicle levels by clearing EVs, with reduced clearance in obesity leading to increased circulating adipoEVs.

Delivery of collagen-encoding mRNA to the skin for cosmetic applications

The paper develops a method to deliver collagen-encoding mRNA topically to improve skin condition by enabling in vivo collagen expression.

Broad brain biodistribution conferred by an AAV to restore TDP-43 function mitigates Frontotemporal Demenia-like deficits

This study uses a BBB-permeable AAV to deliver CTR and restore TDP-43 function in a mouse model of FTLD-TDP, reducing deficits and neuron loss.

ASCOT identifies key regulators of neuronal subtype-specific splicing

ASCOT identifies key regulators of neuronal subtype-specific splicing by analyzing public RNA-Seq data and demonstrating the role of PTBP1, MSI1, and PCBP2 in rod photoreceptor splicing.