Jonathan R. Brestoff

This study shows that inflammaging in aged tissues drives the development of age-associated CD8+ T cells through adipose tissue niches.

The paper shows immune cells regulate circulating adipocyte extracellular vesicle levels by clearing EVs, with reduced clearance in obesity leading to increased circulating adipoEVs.

The paper uses electron microscopy to analyze mitochondrial DNA-containing extracellular vesicles in human biofluids, showing that cf-mtDNA is often associated with double-membrane particles.

This study uses quantum sensors to show that mitochondria in mouse cells regulate temperature and magnetic fields through iron-dependent feedback loops, with altered profiles in a Leigh syndrome model.

This study identifies MXRA8 as a promoter of adipose tissue whitening that drives obesity, showing its role in reducing UCP1 expression and protecting against obesity in mice.

Ibex vectorizes BCR sequences for dimensional reduction and integrates into single-cell analysis workflows.