NeurosciencebioRxivPreprint
G4C2 repeat RNA mediates the disassembly of the nuclear pore complex in C9orf72 ALS/FTD
Alyssa N. Coyne, Benjamin L. Zaepfel, Lindsey R. Hayes…·Jeffrey D. Rothstein
The paper identifies POM121 as a critical nucleoporin affected by C9orf72 repeat RNA, leading to nuclear pore complex disassembly and neuronal toxicity in ALS/FTD.