BiophysicsbioRxivPreprint
Heterochromatin drives organization of conventional and inverted nuclei
Martin Falk, Yana Feodorova, Natasha Naumova…·Leonid Mirny
This paper investigates the mechanism of nuclear inversion in rod photoreceptors by combining Hi-C, microscopy, and polymer modeling, revealing that heterochromatin interactions drive phase separation and that lamina interactions maintain conventional nuclear organization.