NeurosciencebioRxivPreprint
Impaired M-current in KCNQ2 Encephalopathy Evokes Dyshomeostatic Modulation of Excitability
Dina Simkin, Timothy J. Searl, Brandon N Piyevsky…·Evangelos Kiskinis
This study investigates how KCNQ2 mutations affect neuronal excitability in patient-derived neurons, finding progressive hyperexcitability and altered firing patterns linked to impaired M-current.