Genetic & Genomic MedicinemedRxivPreprint
Transdiagnostic Polygenic Risk Models for Psychopathology and Comorbidity: Cross-Ancestry Analysis in the All of Us Research Program
Phil Hyoun Lee, Jae-Yoon Jung, Brandon T. Sanzo…·Andrew David Grotzinger
This study evaluates transdiagnostic polygenic risk scores for psychiatric disorders using the All of Us Research Program data, finding that a common psychiatric genetic factor PRS better predicts comorbidity burden than single-disorder scores.
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