Cancer BiologybioRxivPreprint
Rewiring the fusion oncoprotein EWS/FLI1 in Ewing sarcoma with bivalent small molecules
Michael J. Bond, Ryan P. Golden, Giulia DiGiovanni…·Kimberly Stegmaier
This study develops a bivalent small molecule, EB-TCIP, that relocalizes EWS/FLI1 to induce BCL6 target genes, demonstrating a strategy to target fusion oncoproteins in Ewing sarcoma.