Molecular BiologybioRxivPreprint
Tissue Kallikrein 1 cleaves complement factor C3 and activates the alternative complement pathway
Sarah E. Sartain, Paula M. Jacobi, Virginie Qian…·Andrew Yee
This study shows that KLK1 cleaves complement factor C3 and activates the alternative complement pathway in HSCT-TMA, contributing to endothelial injury and renal dysfunction.