Author

C. A. Carvalheda

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Biophysics· 1

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Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:statistical model· 1 Assay:structural biology· 1

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A. V. Pisliakov· 1 shared o. N. Vickery· 1 shared S. A. Zaidi· 1 shared U. Zachariae· 1 shared V. Katritch· 1 shared

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1 shared paperBiophysics

A. V. Pisliakov

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BiophysicsbioRxivJul 21, 2017

Intracellular Passage Of Na+ In An Active State G Protein Coupled Receptor

o. N. Vickery, C. A. Carvalheda, S. A. Zaidi…·U. Zachariae

This study shows that Na+ ion movement from an extracellular binding site to the cytosol is a key step in GPCR activation, stabilizing active-state conformations.

DOI 10.1016/j.str.2017.11.013

humanstructural biology

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