Author

C. A. Thorne

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Assay:organoid / primary culture· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

A. L. Paek· 2 shared J. Chakrabarti· 2 shared K. W. Pond· 2 shared Y. Zavros· 2 shared A. E. Greenstein· 1 shared A. G. Moraitis· 1 shared A. Livolsi· 1 shared A. N. Kettenbach· 1 shared

Activity by Year

2021-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

A. L. Paek

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Genetically Engineered Human Pituitary Corticotroph Tumor Organoids Exhibit Divergent Responses To Glucocorticoid Receptor Modulators

S. Mallick, J. Chakrabarti, J. Eschbacher, A. G. Moraitis, A. E. Greenstein, J. Churko, K. W. Pond, A. Livolsi, C. A. Thorne, A. S. Little, K. C. Yuen, Y. Zavros

This study uses PitNET organoids to show relacorilant reduces tumor growth and induces apoptosis better than mifepristone, and enhances response to somatostatin analogs.

bioRxiv · Sep 7, 2022Physiology

Live-Cell Imaging in Human Colonic Monolayers Reveals Erk Waves Limit the Stem Cell Compartment to Maintain Epithelial Homeostasis

K. W. Pond, O. Alkhimenok, J. Chakrabarti, Y. Zavros, C. A. Thorne, A. L. Paek

The paper uses live-cell imaging in human colonic organoids to show Erk signaling waves maintain stem cell compartments and tissue homeostasis by restricting stem cell expansion.

bioRxiv · Feb 23, 2022Cell Biology

Feedback in the β-catenin destruction complex imparts bistability and cellular memory

M. J. Cantoria, E. Alizadeh, J. Ravi, N. Bunnag, A. N. Kettenbach, Y. Ahmed, A. L. Paek, J. J. Tyson, K. Doubrovinski, E. Lee, C. A. Thorne

The paper shows that positive feedback in the β-catenin destruction complex creates bistability and memory in Wnt signaling, leading to switch-like cellular responses.

bioRxiv · Jan 28, 2022Cell Biology

Convergent antibody responses to the SARS-CoV-2 spike protein in convalescent and vaccinated individuals

E. C. Chen, P. Gilchuk, S. J. Zost, N. Suryadevara, E. S. Winkler, C. R. Cabel, E. Binshtein, R. E. Sutton, J. L. Rodriguez, S. Day, L. Myers, A. Trivette, J. K. Williams, E. Davidson, S. Li, , J. E. Crowe

The paper identifies public antibody clonotypes in SARS-CoV-2 convalescents and vaccinated individuals, revealing common epitope recognition and potential vaccine efficacy mechanisms.

bioRxiv · May 2, 2021Immunology