Cell BiologybioRxiv
Feedback in the β-catenin destruction complex imparts bistability and cellular memory
M. J. Cantoria, E. Alizadeh, J. Ravi…·C. A. Thorne
The paper shows that positive feedback in the β-catenin destruction complex creates bistability and memory in Wnt signaling, leading to switch-like cellular responses.
DOI 10.1073/pnas.2208787120