Systematic Elucidation and Pharmacological Targeting of Tumor-Infiltrating Regulatory T Cell Master Regulators
A. Obradovic, C. Ager, M. Turunen, T. Nirschl, M. Khosravi-Maharlooei, C. Jackson, V. Yegnasubramanian, A. DeMarzo, C. Kochel, M. Allaf, T. Bivalacqua, M. Lim, C. Karan, C. Drake, A. Califano
The paper identifies 17 master regulators of tumor-infiltrating regulatory T cells (TI-Tregs) and shows that targeting TRPS1 reduces tumor growth and enhances PD-1 inhibitor efficacy.
bioRxiv · Feb 22, 2022Cancer Biology