C. Jackson

Increased stromal densities of B cells, CD103+ cells, and CD163+ M2-like macrophages associate with poor clinical outcomes in BCG treated non-muscle invasive bladder cancer

This study identifies increased stromal densities of B cells, CD103+ cells, and CD163+ M2-like macrophages as predictors of poor clinical outcomes in BCG-treated NMIBC patients.

Distinct Myeloid Derived Suppressor Cell Populations Promote Tumor Aggression in Glioblastoma

This study identifies two unique myeloid-derived suppressor cell populations in glioblastoma that promote tumor growth and immune evasion.

Targeting DNA2 Overcomes Metabolic Reprogramming in Multiple Myeloma

This study identifies DNA2 as a key factor in mitochondrial metabolism that enables multiple myeloma cells to survive DNA damage, showing that targeting DNA2 overcomes metabolic reprogramming and enhances therapy effectiveness.

Native Mass Spectrometry of Complexes Formed by Molecular Glues Reveals Stoichiometric Rearrangement of E3 Ligases

This paper uses native mass spectrometry to study stoichiometric changes in E3 ligase complexes during targeted protein degradation, revealing novel binding mechanisms and salt concentration effects.

Graph neural networks ameliorate potential impacts of imprecise large-scale autonomous immunofluorescence labeling of immune cells on whole slide images

This study uses graph neural networks to improve TIL classification on whole slide images by leveraging contextual features from immunofluorescence labeling.

Systematic Elucidation and Pharmacological Targeting of Tumor-Infiltrating Regulatory T Cell Master Regulators

The paper identifies 17 master regulators of tumor-infiltrating regulatory T cells (TI-Tregs) and shows that targeting TRPS1 reduces tumor growth and enhances PD-1 inhibitor efficacy.

Phylodynamic signatures in the emergence of community-associated MRSA

This study uses phylodynamic methods to analyze the emergence and spread of community-associated MRSA lineages globally, identifying common patterns of epidemic growth and transmission.

Sexual dimorphism in outcomes of non-muscle invasive bladder cancer: a role of CD163+ M2 macrophages, B cells and PD-L1 immune checkpoint.

This study identifies sexual dimorphism in NMIBC immune microenvironment, showing higher CD163+ macrophages and PD-L1 in female tumors, linked to worse recurrence-free survival.

Ectopic histone clipping in the mouse model of progressive myoclonus epilepsy

This study identifies CSTB as a regulator of histone H3 tail clipping in NPCs and links its deficiency to epigenetic dysregulation and impaired mitochondrial function in a mouse model of progressive myoclonus epilepsy.

Septins disruption controls tumor growth and enhances efficacy of Herceptin

The paper develops UR214-9, a compound that disrupts septin filaments in cancer cells, inhibiting growth of HER2+ tumors and enhancing Herceptin efficacy.

Higher-order epistatic networks underlie the evolutionary fitness landscape of a xenobiotic- degrading enzyme

This study identifies five mutations that enable the evolution of a xenobiotic-degrading enzyme and shows that higher-order epistasis shapes its adaptive landscape and substrate specificity.

Recurrent loss of heterozygosity correlates with clinical outcome in pancreatic neuroendocrine cancer

The paper identifies two distinct aneuploidy patterns in pancreatic neuroendocrine tumors (pNETs) associated with poor and good clinical outcomes, respectively, and highlights MEN1 mutations as a significant driver.