M. Lim

Negative regulation of Activation-Induced Cytidine Deaminase gene transcription in developing B cells by a PU.1-interacting intronic region

The paper identifies a PU.1-interacting intronic region that negatively regulates Aicda transcription in developing B cells.

Spatial Transcriptomics Reveals Spatially Diverse Cancer-Associated Fibroblast in Lung Squamous Cell Carcinoma Linked to Tumor Progression

This study uses spatial transcriptomics to analyze cancer-associated fibroblasts in lung squamous cell carcinoma, linking their spatial organization to tumor progression and patient outcomes.

DCAF16-Based Covalent Handle for the Rational Design of Monovalent Degraders

This study identifies a covalent handle that enables the degradation of multiple protein targets when appended to protein-targeting ligands.

SEX-SPECIFIC IMPACTS OF EARLY LIFE SLEEP DISRUPTION: ETHANOL SEEKING, SOCIAL INTERACTION, AND ANXIETY ARE DIFFERENTIALLY ALTERED IN ADOLESCENT PRAIRIE VOLES

The role of positively charged small biomolecules in the aggregation of hyperphosphorylated tau in Alzheimer's disease

This study identifies electrostatic interactions between hyperphosphorylated tau and polyamines as crucial for tau aggregation in Alzheimer's disease and observes the transition from aggregates to fibrils.

Distinct Myeloid Derived Suppressor Cell Populations Promote Tumor Aggression in Glioblastoma

This study identifies two unique myeloid-derived suppressor cell populations in glioblastoma that promote tumor growth and immune evasion.

BRAF/MEK Inhibition Induces Cell State Transitions Boosting Immune CheckpointSensitivity in BRAFV600E-mutant Glioma

This study shows that BRAF/MEK inhibition induces cell state transitions in BRAFV600E-mutant gliomas, leading to PD-L1 upregulation and immune evasion, which can be overcome by combining with immune checkpoint inhibition.

Programmed cell death-1 receptor mediated regulation of Tbet+ NK1.1- Innate Lymphoid Cells within the Tumor Microenvironment

This paper identifies Tbet+NK1.1- ILCs in the tumor microenvironment and shows PD-1 regulates their proliferation and anti-tumor function through metabolic changes.

Predicting and prioritizing community assembly: learning outcomes via experiments

The paper introduces LOVE, a model that predicts and prioritizes community assembly outcomes using experimental data with high accuracy.

Systematic Elucidation and Pharmacological Targeting of Tumor-Infiltrating Regulatory T Cell Master Regulators

The paper identifies 17 master regulators of tumor-infiltrating regulatory T cells (TI-Tregs) and shows that targeting TRPS1 reduces tumor growth and enhances PD-1 inhibitor efficacy.

Epigenome erosion drives neural crest-like phenotypic mimicry in triple-negative breast cancer and other SOX10+ malignancies

The paper identifies SOX10 expression in TNBC and other SOX10+ malignancies, linking it to epigenome erosion and neural crest-like phenotypic mimicry through promoter hypomethylation.

Characterisation of immune cell subsets of tumour infiltrating lymphocytes in brain metastases

The paper characterizes immune cell subsets in brain metastases and finds that low TILs correlate with high VISTA expression and high TILs with activated microglia.

Designing Sub-20 nm Nanocarriers for Small Molecule Delivery: Interplay among Structural Geometry, Assembly Energetics, and Cargo Release Kinetics

This paper examines how structural geometry, assembly energetics, and cargo release kinetics interact in sub-20 nm nanocarriers, showing that small molecule compatibility and release behavior are influenced by these factors.

Design of 18 nm Doxorubicin-loaded 3-helix Micelles: Cellular Uptake and Cytotoxicity in Patient-derived GBM6 Cells

Immunophenotyping of HER4/YAP axis in breast cancer brain metastasis

This study investigates the HER4/YAP axis in breast cancer brain metastasis using patient samples, finding HER4 phosphorylation is specific to BrM but YAP phosphorylation is not a major consequence of HER4 activation.

Tyrosine phosphorylation of ACLY regulates lipid metabolism and oncogenesis in ALK positive Anaplastic Large Cell Lymphoma

This study identifies tyrosine phosphorylation of ACLY at Y682 as a regulatory mechanism linked to lipid metabolism and oncogenesis in ALK-positive ALCL.

Development and evaluation of a rapid on-site water pathogen detection system for water quality monitoring

This paper develops a rapid on-site DNA-based detection system for Pseudomonas aeruginosa with high sensitivity and specificity, reducing detection time to 45 minutes.

Diffusive Flux Analysis of Tumor Vascular Permeability for 3-Helix-Micelles in Comparison to Other Nanoparticles

This paper develops a mathematical model to quantify nanoparticle permeability in tumors using diffusive flux analysis, showing 3-helix-micelles have higher permeability than other nanoparticles in glioblastoma and colon cancer models.

Chemical Impacts of the Microbiome Across Scales Reveal Novel Conjugated Bile Acids

The paper identifies novel conjugated bile acids produced by the microbiome in mice and humans using mass spectrometry and a murine 3D model.

Arabidopsis phytochelatin synthase 1, but not phytochelatin synthesis, functions in extracellular defense against multiple fungal pathogens

This study identifies PCS1 as a moonlighting protein involved in extracellular defense against fungal pathogens in Arabidopsis, independent of its known role in heavy metal detoxification.

A Ubiquitin-Binding Domain that Does Not Bind Ubiquitin

The paper shows that the CUE1 domain of SMARCAD1 interacts with KAP1's RBCC domain through hydrophobic residues in a coiled-coil structure, not through ubiquitin recognition.

Integrative analysis of DNA methylation suggests down-regulation of oncogenic pathways and reduced de-novo mutation in survival outliers of glioblastoma

The paper analyzes DNA methylation in glioblastoma survivors to identify distinct methylation patterns linked to oncogenic pathways and mutation rates.