Author

A. Obradovic

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 2

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:genetic perturbation / CRISPR· 2 Approach:machine learning (classical)· 2 Organism:mouse· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

C. G. Drake· 3 shared A. Califano· 2 shared A. Barlas· 1 shared A. DeMarzo· 1 shared A. Gopalan· 1 shared A. J. Korman· 1 shared A. Jungbluth· 1 shared A. Kung· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersImmunology

C. G. Drake

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Single Cell Analysis of Treatment-Resistant Prostate Cancer: Implications of Cell State Changes for Cell Surface Antigen Targeted Therapies

S. Zaidi, J. Park, J. M. Chan, M. Roudier, J. L. Zhao, A. Gopalan, K. M. Wadosky, R. A. Patel, E. Sayar, W. R. Karthaus, D. H. Kates, O. Chaudhary, T. Xu, I. Masilionis, L. Mazutis, , C. Sawyers

The paper uses single-cell analysis to study how cell surface antigen expression changes in treatment-resistant prostate cancer, revealing transcriptional heterogeneity and shared gene regulatory networks between NEPC and SCLC.

bioRxiv · Apr 9, 2024 · PreprintCancer Biology

KLRG1 marks tumor-infiltrating CD4 T cell subsets associated with tumor progression and immunotherapy response

C. R. Ager, M. Zhang, M. Chaimowitz, S. Bansal, A. Obradovic, M. Rogava, J. C. Melms, P. McCann, C. Spina, C. G. Drake, M. C. Dallos, B. Izar

The paper identifies KLRG1-expressing CD4 T cell subsets linked to tumor progression and immunotherapy response using longitudinal flow cytometry and machine learning.

bioRxiv · Jan 1, 2023Immunology

Case Study of Single-cell Protein Activity Based Drug Prediction for Precision Treatment of Cholangiocarcinoma

A. Obradovic, L. Tomassoni, D. Yu, K. Guillan, K. Souto, E. Fraser, S. Bates, C. G. Drake, Y. Saenger, F. D. Cruz, A. Kung, A. Califano

The paper develops a single-cell framework to prioritize drugs for cholangiocarcinoma by analyzing subpopulations and validating predictions in patient-derived xenografts.

bioRxiv · Feb 28, 2022 · PreprintCancer Biology

Systematic Elucidation and Pharmacological Targeting of Tumor-Infiltrating Regulatory T Cell Master Regulators

A. Obradovic, C. Ager, M. Turunen, T. Nirschl, M. Khosravi-Maharlooei, C. Jackson, V. Yegnasubramanian, A. DeMarzo, C. Kochel, M. Allaf, T. Bivalacqua, M. Lim, C. Karan, C. Drake, A. Califano

The paper identifies 17 master regulators of tumor-infiltrating regulatory T cells (TI-Tregs) and shows that targeting TRPS1 reduces tumor growth and enhances PD-1 inhibitor efficacy.

bioRxiv · Feb 22, 2022Cancer Biology

Castration-mediated IL-8 Promotes Myeloid Infiltration and Prostate Cancer Progression

Z. A. Lopez-Bujanda, M. C. Haffner, M. G. Chaimowitz, N. Chowdhury, N. J. Venturini, A. Obradovic, C. S. Hansen, J. Jackow, K. S. Sfanos, C. J. Bieberich, P. J. Hurley, M. J. Selby, A. J. Korman, A. M. Christiano, A. M. De Marzo, C. G. Drake

This study identifies IL-8 secretion from prostate cancer cells during castration as a driver of myeloid infiltration and cancer progression, suggesting targeting IL-8/CXCR2 with immunotherapy could delay castration resistance.

bioRxiv · May 27, 2019Immunology