High throughput droplet single-cell Genotyping of Transcriptomes (GoT) reveals the cell identity dependency of the impact of somatic mutations
A. S. Nam, K.-T. Kim, R. Chaligne, F. Izzo, C. Ang, G. Abu-Zeinah, N. D. Omans, A. Pastore, J. Taylor, A. Alonso, M. Mariani, J. R. Cubillos-Ruiz, W. Tam, R. Hoffman, J. M. Scandura, , D. A. Landau
This study introduces GoT, a high-throughput method linking single-cell genotypes and transcriptomes, revealing that somatic mutations' transcriptional effects depend on cell identity.
bioRxiv · Oct 16, 2018Cancer Biology