R. Chaligne

Aging limits stemness and tumorigenesis in the lung by reprogramming iron homeostasis

This study shows aging reduces lung stem cell function and suppresses lung cancer by inducing iron deficiency through the NUPR1-lipocalin-2 pathway.

The neuroendocrine transition in prostate cancer is dynamic and dependent on ASCL1

This study identifies ASCL1 as a critical driver of neuroendocrine lineage transition in prostate cancer using an in vivo model and spatial transcriptomics.

Single Cell Analysis of Treatment-Resistant Prostate Cancer: Implications of Cell State Changes for Cell Surface Antigen Targeted Therapies

The paper uses single-cell analysis to study how cell surface antigen expression changes in treatment-resistant prostate cancer, revealing transcriptional heterogeneity and shared gene regulatory networks between NEPC and SCLC.

Metastatic site influences driver gene function in pancreatic cancer

This study shows that metastatic site influences the function of driver genes like SMAD4 in pancreatic cancer, with organ-specific epigenetic states affecting tumor growth.

Progressive plasticity during colorectal cancer metastasis

This study identifies progressive plasticity in colorectal cancer metastases, showing reprogramming into fetal progenitor states and divergent differentiation, linked to poor survival.

Leptomeningeal anti-tumor immunity follows unique signaling principles

The paper investigates IFN-γ signaling in leptomeningeal metastasis and shows its role in recruiting myeloid cells to control tumor growth.

Type 1 interferon perturbates clonal competition by reshaping human blood development

The paper investigates how type 1 interferon affects clonal competition in human blood development by altering HSC differentiation states and clonal fitness.

Chromosome 9p21.3 Coordinates Cell Intrinsic and Extrinsic Tumor Suppression

The paper investigates how 9p21.3 deletions in cancer disable both cell intrinsic and extrinsic tumor suppression by co-deleting CDKN2A/B and type I interferons, leading to immune evasion and metastasis.

Epigenetic plasticity cooperates with emergent cell-cell interactions to drive neoplastic tissue remodeling in the pancreas

The paper uses single-cell analysis to show that epigenetic plasticity and cell-cell interactions drive tissue remodeling in early pancreatic cancer.

Single-cell multi-omics defines the cell-type specific impact of splicing aberrations in human hematopoietic clonal outgrowths

This study introduces GoT-Splice, a multi-omics method to analyze splicing aberrations in human hematopoietic cells, revealing cell-type specific effects of SF3B1 mutations in clonal outgrowths.

Integrated Single-Cell Genotyping and Chromatin Accessibility Charts JAK2V617F Human Hematopoietic Differentiation

This paper develops GoT-ChA to link genotypes to chromatin accessibility in single cells, revealing JAK2V617F mutation-induced epigenetic changes in hematopoietic differentiation.

Application of high-throughput, high-depth, targeted single-nucleus DNA sequencing in pancreatic cancer

This study develops a scalable workflow for targeted single-nucleus DNA sequencing in pancreatic cancer, enabling high-resolution genomic analysis of tumor subclones and normal cells.

Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation

This study uses single-cell multi-omics to show DNMT3A R882 mutations cause hypomethylation and alter progenitor cell fates in clonal hematopoiesis.

Reversal of lineage plasticity in RB1/TP53-deleted prostate cancer through FGFR and Janus kinase inhibition

This study identifies a pharmacological strategy to reverse lineage plasticity in prostate cancer by inhibiting FGFR and Janus kinase pathways.

Multilineage plasticity in prostate cancer through expansion of stem-like luminal epithelial cells with elevated inflammatory signaling

The paper identifies stem-like luminal cells with elevated JAK/STAT signaling as a source of multilineage plasticity in prostate cancer, offering a therapeutic target.

Anatomic position determines oncogenic specificity in melanoma

The paper shows that anatomic position influences oncogenic specificity in melanoma by identifying position-specific gene programs that interact with oncogenes like CRKL.

High throughput droplet single-cell Genotyping of Transcriptomes (GoT) reveals the cell identity dependency of the impact of somatic mutations

This study introduces GoT, a high-throughput method linking single-cell genotypes and transcriptomes, revealing that somatic mutations' transcriptional effects depend on cell identity.