Author

R. Hoffman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 4 Immunology· 1 Pharmacology & Toxicology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 5 Research Focus:differential expression· 5 Approach:experimental assay· 5 Organism:human· 4 Assay:scRNA-seq· 4 Approach:deep learning· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1

Frequent Co-Authors

D. A. Landau· 3 shared P. Smibert· 3 shared R. Chaligne· 3 shared A. Dunbar· 2 shared A. S. Nam· 2 shared B. Marcellino· 2 shared F. Izzo· 2 shared G. Abu-Zeinah· 2 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCancer Biology

D. A. Landau

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

The reparative immunologic consequences of stem cell transplantation as a cellular therapy for refractory Crohn's disease

D. Guisado, S. Talware, X. Wang, A. Davis, E. Fozilov, A. Etra, J.-F. Colombel, C. Schaniel, C. Tasad, J. E. Levine, J. L. M. Ferrara, L.-S. Chuang, K. Sabic, S. Singh, B. K. Marcellino, , L. Cohen

This study investigates how stem cell transplantation (SCT) restores immune function in refractory Crohn's disease by analyzing immune cell remodeling and HSC heterogeneity using single-cell RNA sequencing and functional assays.

bioRxiv · May 30, 2024 · PreprintImmunology

Non-indigenous seaweeds in the Northeast Atlantic Ocean, the Mediterranean Sea and Macaronesia: a critical synthesis of diversity, spatial and temporal patterns

L. M. van der Loos, Q. Bafort, S. Bosch, E. Ballesteros, I. Barbara, E. Bercibar, A. Blanfune, K. Bogaert, S. Bouckenooghe, C.-F. Boudouresque, J. Brodie, E. Cecere, P. Diaz-Tapia, A. H. Engelen, K. Gunnarson, , De

The paper reanalyzes non-indigenous seaweed species in the Northeast Atlantic, Mediterranean Sea, and Macaronesia, revealing diversity patterns and uncertainties in their status.

bioRxiv · Jun 5, 2023Plant Biology

Type 1 interferon perturbates clonal competition by reshaping human blood development

C. Lama, D. Isakov, S. Rosenberg, M. Quijada-Alamo, M. S. Saurty-Seerunghen, S. Moein, T.-A. Abera, O. Sakaguchi, M. Totwani, G. Freed, C.-L. Poon, N. Parghi, A. Kubas-Meyer, A. X. Xie, M. Omar, , A. S. Nam

The paper investigates how type 1 interferon affects clonal competition in human blood development by altering HSC differentiation states and clonal fitness.

bioRxiv · Sep 28, 2022Cancer Biology

Integrated Single-Cell Genotyping and Chromatin Accessibility Charts JAK2V617F Human Hematopoietic Differentiation

R. M. Myers, F. Izzo, S. Kottapalli, T. Prieto, A. Dunbar, R. L. Bowman, E. P. Mimitou, M. Stahl, S. El Ghaity-Beckley, J. Arandela, R. Raviram, S. Ganesan, L. Mekerishvili, R. Hoffman, R. Chaligne, , D. A. Landau

This paper develops GoT-ChA to link genotypes to chromatin accessibility in single cells, revealing JAK2V617F mutation-induced epigenetic changes in hematopoietic differentiation.

bioRxiv · May 11, 2022 · PreprintCancer Biology

CXCL8/CXCR2 signaling mediates bone marrow fibrosis and represents a therapeutic target in myelofibrosis

A. Dunbar, D. Kim, M. Lu, M. Farina, J. L. Yang, Y. Park, F. Gobbo, P. Verachi, F. Martelli, A. Karzai, W. Xiao, L. Xia, N. Elmansy, M. Kleppe, Z. Chen, , R. Hoffman

This study identifies CXCL8/CXCR2 signaling as a driver of bone marrow fibrosis in myelofibrosis and shows its therapeutic potential through genetic and pharmacologic inhibition.

bioRxiv · Dec 8, 2021Cancer Biology

Discovery of a Novel Inhibitor of Coronavirus 3CL Protease as a Clinical Candidate for the Potential Treatment of COVID-19

B. Boras, R. M. Jones, B. J. Anson, D. Arenson, L. Aschenbrenner, M. A. Bakowski, N. Beutler, J. Binder, E. Chen, H. Eng, J. Hammond, R. Hoffman, E. P. Kadar, R. Kania, E. Kimoto, , M. E. McGrath

This study identifies PF-00835321 as a potent inhibitor of SARS-CoV-2 3CL protease with in vitro antiviral activity and clinical evaluation potential.

bioRxiv · Sep 12, 2020 · PreprintPharmacology & Toxicology

High throughput droplet single-cell Genotyping of Transcriptomes (GoT) reveals the cell identity dependency of the impact of somatic mutations

A. S. Nam, K.-T. Kim, R. Chaligne, F. Izzo, C. Ang, G. Abu-Zeinah, N. D. Omans, A. Pastore, J. Taylor, A. Alonso, M. Mariani, J. R. Cubillos-Ruiz, W. Tam, R. Hoffman, J. M. Scandura, , D. A. Landau

This study introduces GoT, a high-throughput method linking single-cell genotypes and transcriptomes, revealing that somatic mutations' transcriptional effects depend on cell identity.

bioRxiv · Oct 16, 2018Cancer Biology