A. Pastore

N-acetylcysteine counteracts immune dysfunction and autistic-related behaviors in the Shank3b mouse model of Autism Spectrum Disorders

This study shows that N-acetylcysteine reduces inflammation and improves social behavior in a Shank3b mouse model of ASD.

The interplay between oxidative stress and inflammation supports autistic-related behaviors in mice

This study shows that oxidative stress and inflammation interact to support autistic-like behaviors in Cntnap2-deficient mice, with NAC treatment improving these behaviors and microglia function.

BIRC3: A Prognostic Predictor and Novel Therapeutic Target in TMZ-Resistant Glioblastoma Tumors

This study identifies BIRC3 as a prognostic biomarker and therapeutic target for TMZ-resistant glioblastoma, validated across multiple datasets and showing efficacy when combined with AZD5582.

Robotics-driven manufacturing of cartilaginous microtissues for the bio-assembly of skeletal implants

This paper develops a robotic system for automated manufacturing of cartilaginous microtissues, showing improved control and differentiation into cartilage and bone.

The disease associated Tau35 fragment has an increased propensity to aggregate compared to full-length tau

The paper compares the aggregation propensity of Tau35 to full-length tau, finding Tau35 aggregates more readily and forms denser structures.

Anatomy of unfolding: The site-specific fold stability of Yfh1 measured by 2D NMR

This study uses 2D NMR to analyze site-specific stability of Yfh1 during cold and heat denaturation, revealing differences between unfolding processes.

Protein structure without structure determination: direct coupling analysis based on in vitro evolution

This study introduces a method to infer protein structure and evolutionary landscape from functional selection without direct structural determination or physical measurements.

A simple linearization method unveils hidden enzymatic assay interferences

This paper introduces a linearization method to detect hidden enzymatic assay interferences by analyzing progress curves in modified coordinates, improving the accuracy of kinetic data selection.

High throughput droplet single-cell Genotyping of Transcriptomes (GoT) reveals the cell identity dependency of the impact of somatic mutations

This study introduces GoT, a high-throughput method linking single-cell genotypes and transcriptomes, revealing that somatic mutations' transcriptional effects depend on cell identity.

The structure of the Pro-domain of mouse proNGF in contact with the NGF domain

This study determines the structure of the pro-domain of mouse proNGF using NMR and SAXS, revealing its intrinsic disorder and functional interactions with mature NGF.

A strategy to study intrinsically mixed folded proteins: The structure in solution of ataxin-3

This paper describes a strategy to assign the NMR spectrum of ataxin-3, revealing structural features of its disordered C-terminal tail and polyglutamine repeats.

Molecular mechanism of the dual regulation of bacterial iron sulfur cluster biogenesis by CyaY and IscX

The paper investigates the interaction between IscX and CyaY in bacterial iron-sulfur cluster assembly, showing IscX modulates CyaY's inhibitory effect on cluster formation.