Rapid changes in chromatin structure during dedifferentiation of primary hepatocytes in vitro
M. Seirup, S. Sengupta, S. Swanson, B. E. McIntosh, M. Collins, L.-F. Chu, Z. Cheng, D. Gorkin, B. Duffin, J. M. Bolin, C. Argus, R. Stewart, J. A. Thomson
This study identifies three phases of hepatocyte dedifferentiation in culture through RNA-seq and ATAC-seq, revealing rapid chromatin changes and fetal gene activation.
bioRxiv · Sep 21, 2020Cell Biology