Z. Cheng

Genomic characterization of Escherichia coli harbor a polyketide synthase (pks) island associated with colorectal cancer (CRC) development

This study characterizes the genomic distribution and evolution of pks islands in E. coli strains associated with colorectal cancer, revealing phylogenetic patterns and horizontal gene transfer.

Marine biofilms: cyanobacteria factories for the global oceans

This study reveals marine biofilms as a major habitat for cyanobacteria, showing distinct diversity and functional adaptations compared to seawater, with diversification linked to key geological events.

The genomic trajectory of ovarian high grade serous carcinoma is determined in STIC lesions

This study shows that high ploidy and whole genome duplication in ovarian high-grade serous carcinoma originate in STIC lesions, indicating early determination of the tumor's genomic trajectory.

Structure-based discovery of positive allosteric modulators for the calcium sensing receptor

The paper uses structure-based virtual screening to identify novel CaSR PAMs with higher potency and reduced side effects compared to existing drugs.

Battery-Free Optoelectronic Patch for Photodynamic and Light Therapies in Treating Bacteria-Infected Wounds

This paper introduces a battery-free optoelectronic patch for photodynamic and light therapies to treat bacterial infections, showing reduced bacterial load and enhanced tissue regeneration in animal models.

Biosynthesis- and Metabolomics-guided discovery of antimicrobial cyclopeptides against drug-resistant clinical isolates

This study discovers new Avi(Me)Cys-containing cyclopeptide antibiotics effective against drug-resistant bacteria using genome mining and metabolomics.

Modeling Cystic Fibrosis Chronic Infection Using Engineered Mucus-like Hydrogels

This study develops mucus-like hydrogels to model cystic fibrosis airway infections and finds that antibiotic resistance depends on both hydrogel properties and culture conditions.

DEC1 is an adult clock regulator that links circadian rhythms to functional β-cell maturation

This study shows DEC1 regulates circadian rhythms in β-cells, linking them to metabolic maturation and glucose responsiveness.

Hybrid Modeling of Engineered Biological Systems through Coupling Data-Driven Calibration of Kinetic Parameters with Mechanistic Prediction of System Performance

This paper develops a hybrid modeling strategy that combines data-driven calibration with mechanistic prediction to improve performance prediction of engineered biological systems.

Bacterial Cytochrome P450-catalyzed Post-translational Macrocyclization

This study identifies and characterizes bacterial P450 enzymes that catalyze post-translational macrocyclization of peptides, expanding the known functional capabilities of P450s.

Pathogen protein modularity enables elaborate mimicry of a host phosphatase

The paper identifies a modular (L)WY-LWY motif in Phytophthora effectors that recruits host PP2A phosphatase, enabling phosphoprotein regulation through structural mimicry.

Anti-CRISPR AcrIIC5 is a dsDNA mimic that inhibits type II-C Cas9 effectors by blocking PAM recognition

This study reveals that AcrIIC5 mimics dsDNA to inhibit type II-C Cas9 by blocking PAM recognition, providing insights into its mechanism and evolutionary convergence.

Enhanced survival and low proliferation marks multifunctional virus specific memory CD4 T cells

The paper identifies multifunctional virus-specific memory CD4 T cells that exhibit enhanced survival and low proliferation, suggesting survival, not proliferation, drives their persistence in the memory pool.

Using spatio-temporal information in weather radar data to detect and track communal bird roosts

This paper develops an AI system to detect and track swallow roosts in weather radar data, improving detection performance with temporal information and reducing human effort.

Structural Analysis of Phosphorylation Proteoforms in a Dynamic Heterogeneous System Using Flash Oxidation Coupled In-Line with Ion Exchange Chromatography

This study uses IEX LC-FOX to analyze structural changes in phosphoproteoforms of ovalbumin during dephosphorylation, revealing residue-level oxidation differences and structural stabilization effects.

Biofunctional matrix models reveal mineral-dependent mechanoregulation of bone metastatic breast cancer

The paper shows that mineralization in bone matrix models inhibits tumor cell proliferation and induces a stem-like phenotype, contradicting the assumption that rigidity promotes metastasis.

Neutrophils reprograms the bone marrow to impair T-cell immunity during tuberculosis

This study shows that neutrophils in tuberculosis promote pathologic hematopoiesis by producing G-CSF, which impairs T-cell immunity through IFNAR1 signaling.

Super-resolution vibrational imaging using expansion stimulated Raman scattering microscopy

The paper introduces MAGNIFIERS, a technique combining SRS microscopy with expansion microscopy to achieve sub-50 nm resolution and scalable multiplexity for label-free chemical imaging.

Topological supramolecular network enabled highly conductive and stretchable organic bioelectronics

This paper introduces a topological supramolecular network strategy to create highly conductive and stretchable organic bioelectronics with unprecedented performance in physiological environments.

Efficient transformation and genome editing of watermelon assisted by genes that encode developmental regulators

This study improves watermelon transformation efficiency using AtGRF5 and Agrobacterium GV3101, achieving 25% efficiency and enabling CRISPR/Cas9-based knockout mutants.

OsMADS58 stabilizes gene regulatory circuits during rice stamen development

This study identifies OsMADS58's role in stabilizing gene regulatory circuits during rice stamen development using CRISPR knockout and transcriptomic analysis.

Dual G9A and EZH2 inhibition stimulates an anti-tumour immune response in ovarian high-grade serous carcinoma

This study shows that dual inhibition of G9A and EZH2 in ovarian cancer enhances anti-tumour immune responses by altering the immune microenvironment and reducing tumour growth.

The genomic landscape of early stage ovarian high grade serous carcinoma

This study compares genomic features of early and late stage high grade serous ovarian carcinoma, finding no unique mutations or focal copy number alterations but noting differences in ploidy and copy number signatures.

Linking Population Dynamics to Microbial Kinetics for Hybrid Modeling of Engineered Bioprocesses

The paper develops a hybrid modeling strategy integrating microbial population dynamics and data-driven approaches to predict bioprocess outcomes with high accuracy.

High resolution ultrasonic neural modulation observedvia in vivo two-photon calcium imaging

This study develops a dual-modality system to investigate high-frequency ultrasound's effect on neuronal activity in awake mice, achieving 100-micron spatial resolution.

In vitro rapid inactivation of SARS-CoV-2 by visible light photocatalysis using boron-doped bismuth oxybromide

This study demonstrates that boron-doped bismuth oxybromide rapidly inactivates SARS-CoV-2 under visible light and in the dark, outperforming conventional photocatalysts.

Analysis of Classic Tomato Mutants Reveals Influence of Leaf Vein Density on Fruit BRIX

The paper analyzes tomato mutants to show leaf vein density negatively correlates with fruit BRIX, linking leaf morphology to fruit sugar levels through gene expression changes.

Phospholipase A2 inhibitor-loaded micellar nanoparticles attenuate inflammation and mitigate osteoarthritis progression

This study develops sPLA2 inhibitor-loaded micellar nanoparticles that reduce inflammation and slow osteoarthritis progression in human and mouse models.

A novel viral protein translation mechanism reveals mitochondria as a target for antiviral drug development

This study identifies a viral protein translation mechanism involving mitochondrial machinery and highlights mitochondria as a target for antiviral drug development.

Self-Organized Amphiphiles are Poor Hydroxyl Radical Scavengers in Fast Photochemical Oxidation of Proteins Experiments

This study investigates whether membrane environments or amphiphiles scavenge hydroxyl radicals in FPOP experiments, finding no significant bulk scavenging effect.