The hydrogen sulfide donor sodium thiosulfate limits inflammation but aggravate smooth muscle cells apoptosis and aneurysm progression in a mouse model of abdominal aortic aneurysm
C. Bechelli, D. Macabrey, F. Caloz, S. Urfer, M. Lambelet, F. Allagnat, S. Deglise
This study shows that sodium thiosulfate (STS), a hydrogen sulfide donor, reduces inflammation but worsens abdominal aortic aneurysm (AAA) progression by promoting smooth muscle cell apoptosis and ECM breakdown in mice.
bioRxiv · Sep 15, 2023 · PreprintPhysiology