Molecular BiologyNucleic Acids ResearchPeer-reviewed
Analyzing Presymptomatic Tissue to Gain Insights into the Molecular and Mechanistic Origins of Late-Onset Degenerative Trinucleotide Repeat Disease
Yongjun Chu, Jiaxin Hu, Hanquan Liang…·V. Vinod Mootha
The paper uses RNAseq to compare presymptomatic and late-stage FECD tissue, finding early splicing and gene expression changes that predict fibrosis and immune activation in late-stage disease.
51 citations