David R. Corey

The paper identifies promoter-targeted duplex RNAs that increase TCF4 expression in Pitt-Hopkins syndrome, supporting their use as a mutation-independent therapeutic strategy.

This study identifies nuclear miRNA:Argonaute complexes and their chromatin-associated RNA targets, showing miRNA-mediated gene silencing occurs in both nucleus and cytoplasm.

The paper tests the effect of CPSF3 inhibitors YT-II-100 and JTE-607 on R-loop formation, finding global increases but no effect on specific R-loop positive control genes.

This study shows lipid-modified siRNAs can inhibit TTR gene expression in the eye via intravitreal injection, suggesting a potential therapy for ocular TTR amyloidosis.

This study shows that nuclear localization of AGO2 in HCT116 cells and human colon tumors can de-repress miRNA targets and enhance cell migration, influenced by cell density, miRNA biogenesis, and miRISC components.

The paper investigates the functional roles of TNRC6 paralogs in RNA-mediated gene expression and splicing using knockout cell lines and RNAseq, finding they are largely redundant with AGO.

This study maps AGO2 binding sites in nuclear RNA and shows miRNAs and intronic regions influence alternative splicing through synthetic RNA experiments.

The paper investigates the relationship between AGO binding in 3'-UTRs and gene repression, finding that AGO binding does not consistently correlate with gene repression.

The paper uses RNAseq to compare presymptomatic and late-stage FECD tissue, finding early splicing and gene expression changes that predict fibrosis and immune activation in late-stage disease.