Costimulation of TLR8 responses by CXCL4 in Human Monocytes Mediated by TBK1-IRF5 Signaling and Epigenomic Remodeling
C. YANG, M. Bachu, Y. Du, C. Brauner, R. Yuan, M. D. Ah Kioon, G. Chesi, F. J. Barrat, L. B. Ivashkiv
This study shows CXCL4 enhances TLR8 responses in human monocytes by promoting inflammatory gene transcription and IL-1β production through TBK1-IRF5 signaling and chromatin remodeling.
bioRxiv · Mar 28, 2022 · PreprintImmunology