L. B. Ivashkiv

This study investigates CXCL4 signaling in human monocytes, identifying NF-κB and TBK1-JNK pathways and a potential role for TLR4, while noting challenges in isolating CXCL4's effects from endotoxin contamination.

This study shows CXCL4 enhances TLR8 responses in human monocytes by promoting inflammatory gene transcription and IL-1β production through TBK1-IRF5 signaling and chromatin remodeling.

This study identifies age-related downregulation of angiogenic, Notch, and Wnt pathways in peri-implant tissue, linked to immune activation and impaired osseointegration in aged mice.

The paper identifies bone marrow stromal cell populations that contribute to implant osseointegration in a mouse model using lineage tracing and single-cell RNA-seq.

This paper establishes a protocol for dissociating cryopreserved synovial tissue to obtain viable cells with preserved transcriptomes and surface markers, enabling high-dimensional analysis of rheumatoid arthritis pathology.

The paper identifies disease-associated fibroblast subsets in rheumatoid arthritis using single-cell transcriptomics and flow cytometry, revealing subset-specific markers and functional differences.