Y. Du

A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo

Clathrin-associated carriers enable recycling through a kiss-and-run mechanism

The paper identifies a novel endocytic recycling mechanism called CARP, which involves clathrin-associated carriers undergoing partial membrane fusion and release.

Spatial organization of PI3K-PI(3,4,5)P3-AKT signaling by focal adhesions

This study identifies focal adhesions as the subcellular hubs organizing PI3K-PI(3,4,5)P3-AKT signaling, showing localized lipid production and AKT activation, and demonstrates that combined inhibition of PI3K and FAK enhances cancer cell suppression.

Realizing Mechanical Frustration at the Nanoscale Using DNA Origami

This paper uses DNA origami to create a nanoscale metastructure that can switch between frustrated and non-frustrated mechanical states, with distinct free energy profiles.

Development of a Time-Resolved Fluorescence Resonance Energy Transfer ultra-high throughput screening assay for targeting SYK and FCER1G interaction

This paper develops a time-resolved fluorescence resonance energy transfer (TR-FRET) assay for screening small molecule inhibitors targeting the SYK and FCER1G interaction, identifying hematoxylin as a hit.

The pioneer transcription factor ELF2 remodels the nucleosome near transcription start sites

This study reveals how ELF2, a pioneer transcription factor, remodels nucleosomes near transcription start sites by unwrapping DNA and exposing chromatin, facilitating transcription initiation.

hESCs-derived organoids achieve liver zonation by LSEC modulation

This study creates zonated liver organoids using hESCs-derived hepatocytes and LSECs, showing that GLP-1RA targets LSECs to alleviate NAFLD.

Human tumor suppressor protein Pdcd4 binds at the mRNA entry channel in 40S small ribosomal subunit

This study determines the structure of Pdcd4 bound to the 40S ribosomal subunit, revealing its binding site and mechanism in translational control.

Identification of Glucosidase II that regulates STIM1 activation dynamics

This study identifies glucosidase II as a regulator of STIM1 activation dynamics by modulating Ca2+ binding affinity and influencing store-operated Ca2+ entry.

Multi-omic Analysis Identifies Glioblastoma Dependency on H3K9me3 Methyltransferase Activity

This study identifies H3K9me3 methyltransferases as key drivers in glioblastoma, showing their association with prognosis, immune response, and drug response through multi-omics analysis.

PFKP regulates AXL-MET oncogenic and metabolic pathways in lung cancer

This study shows PFKP promotes lung cancer progression by interacting with the AXL-MET pathway, beyond its metabolic role in glycolysis.

Structural insights into sphingosine 1-phosphate receptor 4 activation

The paper determines the cryo-EM structure of activated S1PR4, revealing mechanisms of ligand recognition and Gi coupling to aid in developing safer S1PR4 agonists.

Sec23IP recruits the Cohen syndrome factor VPS13B/COH1 to ER exit site-Golgiinterface for tubular ERGIC formation

This study identifies Sec23IP as a VPS13B adaptor that recruits VPS13B to ER exit sites-Golgi interfaces, promoting tubular ERGIC formation and affecting procollagen export, linking it to Cohen syndrome pathogenesis.

Spatiotemporal recruitment of the ubiquitin-specific protease USP8 directs endosome maturation

This study identifies USP8's role in endosome maturation by mediating Rab5-to-Rab7 switch through recruitment by Rabex5 and promotion of SAND-1/Mon1 recruitment.

Image-Based Assessment of Natural Killer Cell Activity against Glioblastoma Stem Cells

This study develops two image-based assays to assess NK cell migration and cytotoxicity against GSCs, aiming to improve NK cell-based immunotherapy for GBM.

Association between the oral microbiome and brain resting state connectivity in schizophrenia

This study investigates the association between oral microbiome composition and brain functional connectivity in schizophrenia, finding significant microbiome shifts and correlations with brain network alterations.

DNA Nanostar Structures with Tunable Auxetic Properties

This paper designs DNA nanostar structures with tunable auxetic properties using DNA origami and sliding mechanisms, enabling reconfigurable nanoscale metamaterials.

A barley MLA receptor is targeted by a non-ribosomal peptide effector of the necrotrophic spot blotch fungus for disease susceptibility

This study identifies Scs6, a barley gene required for susceptibility to the necrotrophic fungus Bipolaris sorokiniana, and shows it is targeted by a non-ribosomal peptide effector.

FASlpr gene dosage tunes the extent of lymphoproliferation and T cell differentiation in lupus

This study shows that FASlpr gene dosage affects lymphoproliferation and T cell differentiation in lupus models, with heterozygous Faslpr leading to increased autoantibodies and Th1 cell skewing.

Structure basis of the phytoplasma effector SAP05 recognition specificities to plant Rpn10 in ubiquitin-independent protein degradation

The paper determines the crystal structure of phytoplasma effector SAP05 bound to plant Rpn10, revealing a ubiquitin-independent degradation mechanism and conserved interaction patterns across species.

PDZD8-FKBP8 tethering complex at ER-mitochondria contact sites regulates mitochondrial complexity

This study identifies FKBP8 as the tethering partner of PDZD8 at ER-mitochondria contact sites, showing their interdependence in regulating mitochondrial morphology.

Surface-active antibiotic production is a multifunctional adaptation for postfire microbes

The paper identifies rhamnolipid methyl esters produced by postfire microbes that enhance antimicrobial activity, motility, and nutrient solubilization, revealing their multifunctional role in postfire adaptation.

Rapid and visual detection of Schistosoma japonicum circulating nucleic acids by CRISPR-Cas12a

This paper develops a CRISPR-Cas12a-based method for detecting Schistosoma japonicum circulating nucleic acids with high sensitivity and specificity, validated using rabbit serum samples.

Phenotypic plasticity shapes biofilm's structure and fluid transport enhancing resilience

The paper investigates how phenotypic plasticity in Bacillus subtilis biofilms enhances resilience through spatial organization and fluid transport properties.

A multiplexed time-resolved fluorescence resonance energy transfer ultrahigh-throughput screening assay for targeting SMAD4-SMAD3-DNA complex

This paper develops a multiplexed TR-FRET assay to screen small molecule inhibitors targeting the SMAD4-SMAD3-DNA complex, identifying gambogic acid and gambogenic acid as potential hits.

Reverse engineering of a pathogenic antibody reveals the molecular mechanism of vaccine-induced immune thrombotic thrombocytopenia

This paper identifies a pathogenic antibody causing VITT, characterizes its structure and function, and reveals the molecular mechanism involving electrostatic interactions and immune complex formation.

Development and validation of NAD+ metabolism-related gene signature in prognosis prediction ofhepatocellular carcinoma

The paper develops and validates a gene signature related to NAD+ metabolism to predict prognosis in hepatocellular carcinoma using gene expression data.

Cryo-EM structures of the human G-protein coupled receptor 1 (GPR1) - Gi protein complexes bound to the full-length chemerin and to its C-terminal nonapeptide

The paper reports cryo-EM structures of GPR1-Gi complexes bound to full-length chemerin and its C-terminal nonapeptide, revealing a 'two-site' interaction model and structural similarities to CMKLR1-Gi complexes.

Dynamically stiffening biomaterials reveal age- and sex-specific differences in pulmonary arterial adventitial fibroblast activation

This study uses dynamic biomaterials to show age and sex differences in hPAAF activation in response to stiffness, linking findings to the estrogen paradox in PAH.

Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2

This study reports cryo-EM structures of HCAR2-Gi1 complexes with agonists, revealing ligand recognition, selectivity, and activation mechanisms for drug design.