Prioritisation of oncology therapeutic targets using CRISPR-Cas9 screening
F. M. Behan, F. Iorio, E. Goncalves, G. Picco, C. M. Beaver, R. Santos, Y. Rao, R. Ansari, S. Harper, D. A. Jackson, R. McRae, R. Pooley, P. Wilkinson, D. Dow, C. Buser-Doepner, , G. J. Mathew
This study uses CRISPR-Cas9 screens in cancer cell lines to identify and prioritize new oncology therapeutic targets based on gene fitness, biomarkers, and tractability.
bioRxiv · Dec 20, 2018Cancer Biology